Cholesteryl ester transfer proteins, reverse cholesterol transport, and atherosclerosis.

  title={Cholesteryl ester transfer proteins, reverse cholesterol transport, and atherosclerosis.},
  author={Can Bruce and Alan Richard Tall},
  journal={Current opinion in lipidology},
  volume={6 5},
Plasma cholesteryl ester transfer protein plays a central role in lipoprotein metabolism by exchanging cholesteryl esters with triglycerides. Human genetic deficiency is associated with increased HDL-cholesterol levels, whereas cholesteryl ester transfer protein overexpression in transgenic mice results in decreased HDL-cholesterol. Thus, it has been proposed that cholesteryl ester transfer protein deficiency is an antiatherogenic state. However, recent observations in human cholesteryl ester… CONTINUE READING
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