Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese.

@article{Chen2008CholesterylET,
  title={Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese.},
  author={Dawei Chen and Jing-fang Yang and Zhe J Tang and Xiu-min Dong and Xiu-li Feng and Shun Yu and Piu Chan},
  journal={Brain research},
  year={2008},
  volume={1187},
  pages={52-7}
}
There is compelling evidence indicating that reduction of high-density lipoprotein (HDL) level is associated with increased risk of Alzheimer's disease (AD). It is known that the levels of HDL are regulated by cholesteryl ester transfer protein (CETP) and several single nucleotide polymorphisms (SNPs) in the CETP gene have been shown to be associated with the levels of HDL. Therefore, it is assumed that the CETP gene is a reasonable candidate for modifying the susceptibility in AD. In the… CONTINUE READING