Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver.

@article{Gauthier2005CholesterylET,
  title={Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver.},
  author={Andr{\'e} Gauthier and Paulina Lau and Xiaohui Zha and Ross W. Milne and Ruth Mcpherson},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 10},
  pages={2177-84}
}
OBJECTIVE To determine whether cholesteryl ester transfer protein (CETP) directly mediates selective uptake of high-density lipoprotein (HDL)-cholesteryl ester (CE) by hepatocytes and to quantify the effects of the CETP inhibitor, torcetrapib, on this process. METHODS AND RESULTS Using adenovirus-mediated CETP (ad-CETP) expression in primary mouse hepatocytes from either wild-type, low-density lipoprotein (LDL) receptor-/- or SR-BI-/- mice, we demonstrate that CETP enhances the selective… CONTINUE READING

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