Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness.

@article{Yue2014CholesterylEA,
  title={Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness.},
  author={Shuhua Yue and Junjie Li and Seung-Young Lee and Hyeon Jeong Lee and Tian Shao and Bing Song and Liang Cheng and Timothy A Masterson and X John{\'e} Liu and Timothy L Ratliff and Ji Xin Cheng},
  journal={Cell metabolism},
  year={2014},
  volume={19 3},
  pages={393-406}
}
Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis at single-cell level in human patient cancerous tissues. Our imaging data revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases. Biochemical study showed that such cholesteryl ester accumulation was a consequence of loss of tumor… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS
125 Citations
68 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 125 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Similar Papers

Loading similar papers…