Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.

@article{Goldstein1980CholesterylEA,
  title={Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.},
  author={Joseph L Goldstein and Yiu Kee Ho and Michael Scott Brown and Thomas L. Innerarity and Robert W. Mahley},
  journal={The Journal of biological chemistry},
  year={1980},
  volume={255 5},
  pages={1839-48}
}
The synthesis and accumulation of cholesteryl esters by monolayers of mouse peritoneal macrophages was stimulated 20- to 160-fold by incubation with beta-migrating very low density lipoproteins (beta-VLDL, density less than 1.006 g/ml) isolated from the plasma of cholesterol-fed dogs. Three other cholesterol-rich lipoprotein fractions obtained from the plasma of the same hypercholesterolemic dogs, including low density lipoprotein (LDL), cholesterol-induced high density lipoprotein (HDLc), and… CONTINUE READING