Cholesteryl Ester Transfer Protein Corrects Dysfunctional High Density Lipoproteins and Reduces Aortic Atherosclerosis in Lecithin Cholesterol Acyltransferase Transgenic Mice*

@article{Foger1999CholesterylET,
  title={Cholesteryl Ester Transfer Protein Corrects Dysfunctional High Density Lipoproteins and Reduces Aortic Atherosclerosis in Lecithin Cholesterol Acyltransferase Transgenic Mice*},
  author={Bernhard Föger and Michael B. Chase and Marcelo J Amar and Boris L. Vaisman and Robert D. Shamburek and Beverly J. Paigen and Jamila Fruchart-Najib and Jorge Paiz and Christine Anne Koch and Robert F. Hoyt and H. Bryan Jr. Brewer and Silvia Santamarina-Fojo},
  journal={The Journal of Biological Chemistry},
  year={1999},
  volume={274},
  pages={36912 - 36920}
}
Expression of human lecithin cholesterol acyltransferase (LCAT) in mice (LCAT-Tg) leads to increased high density lipoprotein (HDL) cholesterol levels but paradoxically, enhanced atherosclerosis. We have hypothesized that the absence of cholesteryl ester transfer protein (CETP) in LCAT-Tg mice facilitates the accumulation of dysfunctional HDL leading to impaired reverse cholesterol transport and the development of a pro-atherogenic state. To test this hypothesis we cross-bred LCAT-Tg with CETP… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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