Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and 'selective' pathway connection.

  title={Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and 'selective' pathway connection.},
  author={Salman Azhar and S Leers-sucheta and Eve P. Reaven},
  journal={Frontiers in bioscience : a journal and virtual library},
A constant supply of cholesterol is needed as a substrate for steroid hormone synthesis in steroidogenic tissues. Although there are three potential sources, which could contribute to the 'cholesterol pool', needed for steroidogenesis (i.e., de novo synthesis, hydrolysis of stored cholesteryl esters and exogenous lipoproteins), current evidence suggests that plasma lipoproteins are the major source of cholesterol for steroid production in adrenal gland, ovary and, under certain conditions… CONTINUE READING

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