Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.

@article{Kristiana2012CholesterolTT,
  title={Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.},
  author={Ika Febrian Kristiana and Winnie Luu and Julian Stevenson and Si{\^a}n P Cartland and Wendy K Jessup and Jitendra D. Belani and Scott D Rychnovsky and Andrew J Brown},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 40},
  pages={
          33897-904
        }
}
How cholesterol is sensed to maintain homeostasis has been explained by direct binding to a specific protein, Scap, or through altering the physical properties of the membrane. The enantiomer of cholesterol (ent-cholesterol) is a valuable tool in distinguishing between these two models because it shares nonspecific membrane effects with native cholesterol (nat-cholesterol), but not specific binding interactions. This is the first study to compare ent- and nat-cholesterol directly on major… CONTINUE READING

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