Cholesterol synthesis rate in human hippocampus declines with aging.

  title={Cholesterol synthesis rate in human hippocampus declines with aging.},
  author={Karin Maria Thelen and Peter Falkai and T. A. Bayer and Dieter L{\"u}tjohann},
  journal={Neuroscience letters},
  volume={403 1-2},
During the last three to four decades, interest in the interaction of circulating and brain cholesterol has increased. As the CNS matures and cholesterol pools in the brain become constant, the rate of de novo synthesis of cholesterol in the brain is expected to decline. We measured cholesterol, its precursors and its brain specific metabolite 24S-hydroxycholesterol in hippocampus from 7 female and 13 male corpses by highly sensitive and specific gas chromatography-mass spectrometry. Two age… CONTINUE READING

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