Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin.

@article{BoeszeBattaglia2006CholesterolrichMM,
  title={Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin.},
  author={Kathleen Boesze-Battaglia and Dave Besack and Terry Mckay and Ali Zekavat and Linda Otis and Kelly L Jordan-Sciutto and Bruce J. Shenker},
  journal={Cellular microbiology},
  year={2006},
  volume={8 5},
  pages={
          823-36
        }
}
We have previously shown that Actinobacillus actinomycetemcomitans cytolethal-distending toxin (Cdt) is a potent immunosuppressive agent that induces G2/M arrest in human lymphocytes. In this study, we explored the possibility that Cdt-mediated immunotoxicity involves lipid membrane microdomains. We first determined that following treatment of Jurkat cells with Cdt holotoxin all three Cdt subunits localize to these microdomains. Laser confocal microscopy was employed to colocalize the subunits… CONTINUE READING
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