Cholesterol regulates polymodal sensory transduction in Müller glia.

Abstract

Over- and underexposure to cholesterol activates glia in neurodegenerative brain and retinal diseases but the molecular targets of cholesterol in glial cells are not known. Here, we report that disruption of unesterified membrane cholesterol content modulates the transduction of chemical, mechanical and temperature stimuli in mouse Müller cells. Activation… (More)
DOI: 10.1002/glia.23213

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