Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus.

@article{Fester2009CholesterolpromotedSR,
  title={Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus.},
  author={Lars Fester and Lepu Zhou and Andrea B{\"u}tow and Cornelia Huber and Richard von Lossow and Janine Prange-Kiel and Hubertus Jarry and Gabriele M Rune},
  journal={Hippocampus},
  year={2009},
  volume={19 8},
  pages={692-705}
}
Cholesterol of glial origin promotes synaptogenesis (Mauch et al., (2001) Science 294:1354-1357). Because in the hippocampus local estradiol synthesis is essential for synaptogenesis, we addressed the question of whether cholesterol-promoted synapse formation results from the function of cholesterol as a precursor of estradiol synthesis in this brain area. To this end, we treated hippocampal cultures with cholesterol, estradiol, or with letrozole, a potent aromatase inhibitor. Cholesterol… CONTINUE READING

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