Cholesterol perturbing agents inhibit NMDA-dependent calcium influx in rat hippocampal primary culture.

@article{Frank2004CholesterolPA,
  title={Cholesterol perturbing agents inhibit NMDA-dependent calcium influx in rat hippocampal primary culture.},
  author={Claudio Frank and Anna Maria Giammarioli and Rita Pepponi and Carla Fiorentini and S. Rufini},
  journal={FEBS letters},
  year={2004},
  volume={566 1-3},
  pages={25-9}
}
The present study was carried out to investigate the potential involvement of cholesterol-rich membrane microdomains in the mobilization of calcium induced by NMDA-receptors (NMDA-R). We herein provide evidence that agents interfering with plasma membrane cholesterol (namely, filipin and methyl-beta-cyclodextrin (Cdex)) inhibit the NMDA-stimulated influx of calcium in hippocampal cells in culture. Filipin-treated cells maintained their morphology and were able to respond with a calcium influx… CONTINUE READING