Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles.

@article{Lange2000CholesterolMI,
  title={Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles.},
  author={Yvonne Lange and Jin Ye and Mike Rigney and T. Steck},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 23},
  pages={17468-75}
}
Cholesterol accumulates to massive levels in cells from Niemann-Pick type C (NP-C) patients and in cells treated with class 2 amphiphiles that mimic NP-C disease. This behavior has been attributed to the failure of cholesterol released from ingested low density lipoproteins to exit the lysosomes. However, we now show that the rate of movement of cholesterol from lysosomes to plasma membranes in NP-C cells is at least as great as normal, as was also found previously for amphiphile-treated cells… CONTINUE READING

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