Cholesterol modulates the dimer interface of the β₂-adrenergic receptor via cholesterol occupancy sites.

@article{Prasanna2014CholesterolMT,
  title={Cholesterol modulates the dimer interface of the β₂-adrenergic receptor via cholesterol occupancy sites.},
  author={Xavier Prasanna and Amitabha Chattopadhyay and Durba Sengupta},
  journal={Biophysical journal},
  year={2014},
  volume={106 6},
  pages={1290-300}
}
The β2-adrenergic receptor is an important member of the G-protein-coupled receptor (GPCR) superfamily, whose stability and function are modulated by membrane cholesterol. The recent high-resolution crystal structure of the β2-adrenergic receptor revealed the presence of possible cholesterol-binding sites in the receptor. However, the functional relevance… CONTINUE READING