Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells.

@article{AbuArish2015CholesterolMC,
  title={Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells.},
  author={Asmahan Abu-Arish and Elvis Pand{\vz}i{\'c} and Julie Goepp and Elizabeth Matthes and John W. Hanrahan and Paul W Wiseman},
  journal={Biophysical journal},
  year={2015},
  volume={109 1},
  pages={85-94}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) is a plasma-membrane anion channel that, when mutated, causes the disease cystic fibrosis. Although CFTR has been detected in a detergent-resistant membrane fraction prepared from airway epithelial cells, suggesting that it may partition into cholesterol-rich membrane microdomains (lipid rafts), its compartmentalization has not been demonstrated in intact cells and the influence of microdomains on CFTR lateral mobility is unknown… CONTINUE READING

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