Cholesterol lowering property of garlic (Allium sativum) on patients with hypercholesterolemia

@article{Lachhiramka2016CholesterolLP,
  title={Cholesterol lowering property of garlic (Allium sativum) on patients with hypercholesterolemia},
  author={Preety Lachhiramka and Sujay Patil},
  journal={International Journal of Medical Science and Public Health},
  year={2016},
  volume={5},
  pages={2249-2251}
}
Background: Cardiovascular disease especially atherosclerotic coronary heart disease (CHD) accounts for a large population of all deaths and disability worldwide. Elevated lipid levels have a strong association with cardiovascular events. Objectives: Study aim is to reduce cholesterol levels with garlic supplementation. Materials and Methods: It is a prospective, interventional open-label study to see the effect of garlic on serum cholesterol levels. Study was conducted in the Department… 

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References

SHOWING 1-10 OF 16 REFERENCES

Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients

Garlic tablet has significant favorable effect on cholesterol, LDL-cholesterol, and HDL-ch cholesterol, and Garlic may play an important role in therapy of hypercholesterolemia.

Effect of garlic on serum lipids: an updated meta-analysis.

Garlic preparations might be considered as an alternative option with a higher safety profile than conventional cholesterol-lowering medications in patients with slightly elevated cholesterol, provided garlic is used for longer than 2 months.

Neuroprotective Effects of Garlic A Review

The broad range of anti-atherogenic, antioxidant and anti-apoptotic protection afforded by garlic may be extended to its neuroprotective action, helping to reduce the risk of dementia, including vascular dementia and AD.

Effect of garlic on cardiovascular disorders: a review

This review has attempted to make a bridge the gap between experimental and clinical study and to discuss the possible mechanisms of such therapeutic actions of garlic.

Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies.

The results of these studies indicate that the cholesterol-lowering effects of garlic extract, such as AGE, stem in part from inhibition of hepatic cholesterol synthesis by water-soluble sulfur compounds, especially SAC.

A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids.

It is concluded that dietary supplementation with aged garlic extract has beneficial effects on the lipid profile and blood pressure of moderately hypercholesterolemic subjects.

Retraction Note: High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet

The data demonstrate that GE has protective effects on HDL in rats with high LDL intake, and could be used to remedy hypercholesterolemia with help reduce risk of coronary heart disease.

Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men.

  • A. AdlerB. Holub
  • Medicine, Biology
    The American journal of clinical nutrition
  • 1997
Coadministration of garlic with fish oil was well-tolerated and had a beneficial effect on serum lipid and lipoprotein concentrations by providing a combined lowering of total cholesterol, LDL-C, and triacylglycerol concentrations.

Jeremiah Metzger Lecture: cholesterol, inflammation and atherosclerotic cardiovascular disease: is it all LDL?

  • A. Gotto
  • Medicine, Biology
    Transactions of the American Clinical and Climatological Association
  • 2011
A growing body of evidence suggests that measures of inflammation, such as C-reactive protein (CRP), may enhance cardiovascular risk assessment and help guide clinical decision-making, and that reductions in LDL cholesterol are associated with reduced risk for coronary heart disease (CHD).

Effect of garlic on high fat induced obesity.

Garlic affected the down regulation of expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptor γ (PPARγ), acetyl CoA carboxylase (ACC), adipose specific fatty acid binding protein (aP2), and glycerol-3-phosphate dehydrogenase (GPDH).