Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice.

Abstract

The hypocholesterolemic potential of peroxisome proliferator-activated receptor (PPAR) pan-activator bezafibrate has been documented. However, in addition to uncertainty about the contribution of PPAR alpha to its effect, there is a marked discrepancy in bezafibrate dosages used in previous rodent experiments (> or = 50 mg/kg/day) and those in clinical use… (More)
DOI: 10.1016/j.bcp.2008.04.001

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@article{Nakajima2008CholesterolloweringEO, title={Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice.}, author={Takero Nakajima and Naoki Tanaka and Eiko Sugiyama and Yuji Kamijo and Atsushi Hara and Rui Hu and Gang Li and Yufeng Li and Kozo Nakamura and Frank J. Gonzalez and Toshifumi Aoyama}, journal={Biochemical pharmacology}, year={2008}, volume={76 1}, pages={108-19} }