Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro.

@article{Martin2008CholesterolLE,
  title={Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro.},
  author={Mauricio G. Martin and Simona Perga and Laura Trov{\`o} and Andrea Rasola and Pontus Holm and Tomi Rantam{\"a}ki and Tibor Harkany and Eero Castr{\'e}n and Federica Chiara and Carlos G Dotti},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 5},
  pages={
          2101-12
        }
}
Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during embryonic development. In the aged brain, however, BDNF levels are low, suggesting that if TrkB is to play a role in survival at this stage additional mechanisms must have developed. We here show that TrkB activity is most robust in the hippocampus of 21-d-old BDNF-knockout mice as well as in old, wild-type, and BDNF heterozygous animals. Moreover, robust TrkB activity… CONTINUE READING