Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes.

@article{Zhu2016CholesterolIR,
  title={Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes.},
  author={Yanqi Zhu and Caimei Zhang and Biyi Chen and Rong Chen and Ang Guo and Jiang Hong and Long-sheng Song},
  journal={Journal of molecular and cellular cardiology},
  year={2016},
  volume={97},
  pages={204-12}
}
BACKGROUNDS Low serum cholesterol levels are associated with cardiac arrhythmias and poor prognosis in patients with chronic heart failure. However, the underlying mechanisms by which decreases in cholesterol content lead to cardiac dysfunction remain unclear. Multiple studies have implicated damage to cardiac transverse (T)-tubules as a key mediator of excitation-contraction (E-C) coupling dysfunction and heart failure. Since the T-tubule membrane system is enriched in cholesterol, we… CONTINUE READING