Cholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia.

  title={Cholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia.},
  author={Takashi Miida and Satoshi Hirayama and Yuichi Nakamura},
  journal={Journal of atherosclerosis and thrombosis},
  volume={11 5},
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or "statins", are used as cholesterol-lowering agents worldwide. Statins inhibit cholesterol biosynthesis, leading to enhanced uptake of low-density lipoprotein (LDL) from the circulation via LDL receptors. This strong cholesterol-lowering action contributes to the beneficial effects of statins. For example, large clinical trials have demonstrated that statins significantly reduce cardiovascular risk. Recent research has… CONTINUE READING
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