Cholesterol in bilayers with PUFA chains: doping with DMPC or POPC results in sterol reorientation and membrane-domain formation.

@article{Kuerka2010CholesterolIB,
  title={Cholesterol in bilayers with PUFA chains: doping with DMPC or POPC results in sterol reorientation and membrane-domain formation.},
  author={Norbert Ku{\vc}erka and Drew Marquardt and Thad A Harroun and Mu-Ping Nieh and Stephen R. Wassall and Djurre H. de Jong and Lars V. Sch{\"a}fer and Siewert J. Marrink and John Katsaras},
  journal={Biochemistry},
  year={2010},
  volume={49 35},
  pages={7485-93}
}
Using neutron diffraction Harroun et al. [(2006) Biochemistry 45, 1227-1233; (2008) Biochemistry 47, 7090-7096] carried out studies that unequivocally demonstrated cholesterol preferentially sequestering in the middle of bilayers (i.e., flat orientation) made of lipids with polyunsaturated fatty acids (PUFA), in contrast to its "usual" position where its hydroxyl group locates near the lipid/water interface (i.e., upright orientation). Here we clearly show, using neutron diffraction… CONTINUE READING
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