Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol.

@article{Lange2008CholesterolHA,
  title={Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol.},
  author={Yvonne Lange and T. Steck},
  journal={Progress in lipid research},
  year={2008},
  volume={47 5},
  pages={319-32}
}
We review evidence that sterols can form stoichiometric complexes with certain bilayer phospholipids, and sphingomyelin in particular. These complexes appear to be the basis for the formation of condensed and ordered liquid phases, (micro)domains and/or rafts in both artificial and biological membranes. The sterol content of a membrane can exceed the complexing capacity of its phospholipids. The excess, uncomplexed membrane sterol molecules have a relatively high escape tendency, also referred… CONTINUE READING

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