Cholesterol for synthesis of myelin is made locally, not imported into brain.

  title={Cholesterol for synthesis of myelin is made locally, not imported into brain.},
  author={Helga Jurevics and Pierre Morell},
  journal={Journal of neurochemistry},
  volume={64 2},
We examined whether cholesterol needed for myelin formation is locally synthesized or whether it comes from the circulation. The experimental design was to inject [3H]water and to use incorporation of label into brain cholesterol as a measure of the rate of accumulation of newly synthesized cholesterol in brain. The contribution of the circulation to this labeled cholesterol pool was minimized by repressing liver synthesis of cholesterol with a high cholesterol diet. The rate of accumulation of… CONTINUE READING
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