Cholesterol esters regulate apoB48 secretion in CaCo2 cells.

  title={Cholesterol esters regulate apoB48 secretion in CaCo2 cells.},
  author={Sebely Pal and Emma M. Allister and Andrew Thomson and John C. L. Mamo},
  volume={161 1},
In this study, we investigated the effect of atorvastatin, an HMG-CoA reductase inhibitor and CL277082, an ACAT inhibitor, on apolipoprotein B48 synthesis, degradation and secretion in transformed human intestinal enterocytes (CaCo2 cells). Cells were incubated with atorvastatin or CL277082 in the absence or presence of sterol containing media and pulsed with [S35]-methionine and chased with unlabelled methionine. Concomitantly, the effect of atorvastatin and CL277082 on the relative amount of… CONTINUE READING