Cholesterol epoxide is a direct-acting mutagen.

  title={Cholesterol epoxide is a direct-acting mutagen.},
  author={Alex Sevanian and Andrew R. Peterson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={81 13},
A 24-hr treatment of V79 Chinese hamster lung fibroblasts with 12.4 microM cholesterol 5 alpha, 6 alpha-epoxide induced 8-azaguanine-resistant mutants at frequencies 4.6- to 11.8-fold higher than the spontaneous mutation rate. We show that cholesterol epoxide, which is produced by in vivo cholesterol oxidation, is a weak direct-acting mutagen. Cholesterol epoxide was found to be accumulated by cells and transformed to cholestane-3 beta, 5 alpha, 6 beta-triol, which was more toxic and a more… CONTINUE READING
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