Cholesterol enrichment enhances expression of sterol-carrier protein-2: implications for its function in intracellular cholesterol trafficking.

@article{Kraemer1995CholesterolEE,
  title={Cholesterol enrichment enhances expression of sterol-carrier protein-2: implications for its function in intracellular cholesterol trafficking.},
  author={Rosemary Kraemer and Kenneth B. Pomerantz and S Kesav and Terence J. Scallen and David P. Hajjar},
  journal={Journal of lipid research},
  year={1995},
  volume={36 12},
  pages={
          2630-8
        }
}
Cholesterol enrichment of vascular smooth muscle cells, as occurs under conditions of hypercholesterolemia and atherosclerosis, is accompanied by specific changes in cholesterol metabolism and in intracellular cholesterol trafficking. Sterol-carrier protein-2 (SCP2), an intracellular lipid binding protein, enhances the activation of enzymes involved in cholesterol metabolism. It may also enhance cholesterol efflux by regulating the size of the "fast" cholesterol pool available for efflux to… CONTINUE READING

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