Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles.

@article{Vikstedt2007CholesterolEF,
  title={Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles.},
  author={Riikka Vikstedt and Jari Metso and J. Hakala and Vesa M Olkkonen and Christian P Ehnholm and Matti S Jauhiainen},
  journal={Biochemistry},
  year={2007},
  volume={46 42},
  pages={11979-86}
}
Phospholipid transfer protein (PLTP) is expressed by macrophage-derived foam cells in human atherosclerotic lesions, suggesting a regulatory role for PLTP in cellular cholesterol homeostasis. However, the exact role of PLTP in the reverse cholesterol transport pathway is not known. PLTP is present in plasma as two forms, a highly active (HA-PLTP) and a lowly active (LA-PLTP) form. In this study we clarify the role of the two forms of PLTP in cholesterol efflux from [3H]cholesterol oleate-acetyl… CONTINUE READING