Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation.

@article{Theret1990CholesterolEF,
  title={Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation.},
  author={N. Theret and Christiane Delbart and G A Aguie and Jean Charles Fruchart and Georges Vassaux and G{\'e}rard Ailhaud},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={173 3},
  pages={1361-8}
}
Apolipoprotein A-I (apo A-I)*/DMPC complexes have been previously shown to promote cholesterol efflux from cholesterol-preloaded adipose cells whereas apo A-II/DMPC complexes, which bind to the same cell surface binding sites, were ineffective. Addition of apo A-I/DMPC complexes led to a rapid and transient formation of diacylglycerol. However, in contrast to PGF2 alpha (Doglio et al., Proc. Natl. Acad. Sci. USA, 1989, 86, 1148), no accumulation of inositol phosphates was observed. Apo A-II… CONTINUE READING

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