Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide.

@article{Buxbaum2001CholesterolDW,
  title={Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide.},
  author={Joseph D. Buxbaum and Neil S.M. Geoghagen and Lawrence T. Friedhoff},
  journal={Journal of Alzheimer's disease : JAD},
  year={2001},
  volume={3 2},
  pages={221-229}
}
Epidemiological studies have demonstrated that hypercholsterolemia is a significant risk factor for Alzheimer's disease (AD). The mechanism by which increased cholesterol may contribute to AD is unknown. However, as the generation and accumulation of the amyloid Abeta peptide in the brain appears to be significant for the initiation and progression of AD, it is possible that cholesterol levels can regulate Abeta formation and/or clearance. To test the effects of altering cholesterol on Abeta… CONTINUE READING

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