Cholesterol depletion suppresses the translational diffusion of class II major histocompatibility complex proteins in the plasma membrane.

@article{Vrljic2005CholesterolDS,
  title={Cholesterol depletion suppresses the translational diffusion of class II major histocompatibility complex proteins in the plasma membrane.},
  author={Marija Vrljic and Stefanie Y Nishimura and W E Moerner and H. M. Mcconnell},
  journal={Biophysical journal},
  year={2005},
  volume={88 1},
  pages={334-47}
}
Glycosylphosphatidylinositol (GPI)-linked and native major histocompatibility complex class II I-E(k) were used as probes to determine the effect of varying cholesterol concentration on the mobility of proteins in the plasma membrane. These proteins were imaged in Chinese hamster ovary cells using single-molecule fluorescence microscopy. Observed diffusion coefficients of both native and GPI-linked I-E(k) proteins were found to depend on cholesterol concentration. As the cholesterol… CONTINUE READING

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