Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

@article{Simons1998CholesterolDI,
  title={Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.},
  author={Mikael Simons and Patrick Keller and Bart De Strooper and Konrad Beyreuther and Carlos G Dotti and Kai Simons},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 11},
  pages={6460-4}
}
The amyloid precursor protein (APP) plays a crucial role in the pathogenesis of Alzheimer's disease. During intracellular transport APP undergoes a series of proteolytic cleavages that lead to the release either of an amyloidogenic fragment called beta-amyloid (Abeta) or of a nonamyloidogenic secreted form consisting of the ectodomain of APP (APPsec). It is Abeta that accumulates in the brain lesions that are thought to cause the disease. By reducing the cellular cholesterol level of living… CONTINUE READING
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