Cholesterol dependent downregulation of mouse and human apical sodium dependent bile acid transporter (ASBT) gene expression: molecular mechanism and physiological consequences.

@article{Thomas2006CholesterolDD,
  title={Cholesterol dependent downregulation of mouse and human apical sodium dependent bile acid transporter (ASBT) gene expression: molecular mechanism and physiological consequences.},
  author={Craig Thomas and J-F Landrier and Danielle Gaillard and Jacques Grober and M-C Monnot and Anne Athias and Philippe Besnard},
  journal={Gut},
  year={2006},
  volume={55 9},
  pages={
          1321-31
        }
}
BACKGROUND AND AIMS Faecal bile acid elimination greatly contributes to cholesterol homeostasis. Synthesised from cholesterol in the liver, bile acids are actively reclaimed in the ileum by the apical sodium dependent bile acid transporter (ASBT). Although the expression level of ASBT affects body cholesterol balance, the impact of cholesterol on ASBT gene expression remains unclear. In this study, the effect of cholesterol on ASBT expression and ileal bile acid uptake was explored in vivo and… CONTINUE READING
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