Cholesterol crystals impede nerve repair

@article{Chen2018CholesterolCI,
  title={Cholesterol crystals impede nerve repair},
  author={Yanan Chen and Brian Popko},
  journal={Science},
  year={2018},
  volume={359},
  pages={635 - 636}
}
Cholesterol deposits in phagocytic cells disrupt the repair of demyelinated axons Damage to the myelin sheath that surrounds nerve axons represents the pathological hallmark of the neurological disorder multiple sclerosis (MS) and is thought to contribute to a number of other nervous system maladies (1). Remyelination, a regenerative process that forms new myelin sheaths around demyelinated axons, restores nerve function and reverses the clinical manifestations associated with demyelination (2… 
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4 Citations

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TLDR
A comprehensive review of microglial myelin Phagocytosis and its involvement in MS development and repair is provided and the potential of phagocytic-mediated therapeutic approaches is discussed and their modulation is encouraged as a novel and rational approach to ameliorate MS-associated pathology.
Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury
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The recent findings in OL biology are reviewed in the context of the CNS physiological and pathological conditions, focusing on extrinsic factors that facilitate OL development and regeneration.
Comprehensive Analysis of Age-related Changes in Lipid Metabolism and Myelin Sheath Formation in Sciatic Nerves.
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Neutrophils promote clearance of nuclear debris following acid-induced lung injury.
TLDR
A novel mechanism as part of the inflammatory response is shown, in which neutrophils engulf and degrade extracellular DNA fragments and allow for optimal organ repair.

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