Cholesterol crystals impede nerve repair

@article{Chen2018CholesterolCI,
  title={Cholesterol crystals impede nerve repair},
  author={Yanan Chen and B. Popko},
  journal={Science},
  year={2018},
  volume={359},
  pages={635 - 636}
}
  • Yanan Chen, B. Popko
  • Published 2018
  • Medicine
  • Science
  • Cholesterol deposits in phagocytic cells disrupt the repair of demyelinated axons Damage to the myelin sheath that surrounds nerve axons represents the pathological hallmark of the neurological disorder multiple sclerosis (MS) and is thought to contribute to a number of other nervous system maladies (1). Remyelination, a regenerative process that forms new myelin sheaths around demyelinated axons, restores nerve function and reverses the clinical manifestations associated with demyelination (2… CONTINUE READING
    2 Citations
    Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis
    • PDF
    Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury
    • 1
    • PDF

    References

    SHOWING 1-10 OF 15 REFERENCES
    Rejuvenation of regeneration in the aging central nervous system.
    • 427
    • PDF
    Retinoid X receptor gamma signaling accelerates CNS remyelination
    • 357
    • PDF
    Oligodendrocytes: Myelination and Axonal Support.
    • 251
    • PDF
    Oligodendrocyte Development and Plasticity.
    • 173
    • PDF
    Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum
    • 46
    • PDF
    Regenerating CNS myelin — from mechanisms to experimental medicines
    • 171
    • PDF