Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate

@article{Rothberg1990CholesterolCT,
  title={Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate},
  author={K G Rothberg and Y s Ying and Barton A. Kamen and Richard G. W. Anderson},
  journal={The Journal of Cell Biology},
  year={1990},
  volume={111},
  pages={2931 - 2938}
}
The folate receptor is a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein that mediates the delivery of 5-methyltetrahydrofolate to the cytoplasm of MA104 cells. Ordinarily the receptor is sequestered into numerous discrete clusters that are associated with an uncoated pit membrane specialization called a caveola. By using two different methodological approaches, we found that the maintenance of both receptor clusters and caveolae depends upon the presence of cholesterol in the… CONTINUE READING
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