Cholesterol content drives distinct pharmacological behaviours of micro-opioid receptor in different microdomains of the CHO plasma membrane.

@article{Gaibelet2008CholesterolCD,
  title={Cholesterol content drives distinct pharmacological behaviours of micro-opioid receptor in different microdomains of the CHO plasma membrane.},
  author={G{\'e}rald Gaibelet and Claire Millot and Chantal Lebrun and St{\'e}phanie Ravault and Aude Sauli{\`e}re and Aurore Andr{\'e} and Bernard Lagane and Aracelys L{\'o}pez},
  journal={Molecular membrane biology},
  year={2008},
  volume={25 5},
  pages={423-35}
}
Cholesterol in the plasma membrane of eukaryotic cells contributes to modulating the functions and signalling pathways of numerous transmembrane proteins, including G protein Coupled Receptors (GPCRs). We have previously shown that the function of the human micro-opioid receptor (hMOR) expressed in Saccharomyces cerevisiae is modulated by sterols including… CONTINUE READING