Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

@article{Habchi2018CholesterolCA,
  title={Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.},
  author={Johnny Habchi and Sean Chia and C{\'e}line Galvagnion and Thomas C. T. Michaels and Mathias M. J. Bellaiche and Francesco Simone Ruggeri and Michele Sanguanini and Ilaria Idini and Janet R Kumita and Emma Sparr and Sara Linse and Christopher M. Dobson and Tuomas P. J. Knowles and Michele Vendruscolo},
  journal={Nature chemistry},
  year={2018},
  volume={10 6},
  pages={
          673-683
        }
}
Alzheimer's disease is a neurodegenerative disorder associated with the aberrant aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol in the pathogenesis of Alzheimer's disease, the detailed mechanistic link between this lipid molecule and the disease process remains to be fully established. To address this problem, we adopt a kinetics-based strategy that reveals a specific catalytic role of cholesterol in the aggregation of Aβ42 (the 42-residue form of the… CONTINUE READING
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