Cholesterol biosynthesis and metabolism

  title={Cholesterol biosynthesis and metabolism},
  author={D. W. Russell},
  journal={Cardiovascular Drugs and Therapy},
Cholesterol plays an essential role in cell membrane synthesis and in cell growth and differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors or taken up from dietary or exogenous sources. The major catabolic route for disposal of cholesterol involves conversion into excretable bile acids. The maintenance of cholesterol homeostasis is influenced and carefully controlled by multiple feedback mechanisms. The key regulatory targets of these feedback mechanisms… CONTINUE READING


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