Cholesterol-based anionic long-circulating cisplatin liposomes with reduced renal toxicity.

Abstract

Cholesterol anchored derivatives of 5-Cholestene-3-beta-ol 3-hemisuccinate (CHO-HS) and 1-cholesteryl-4-ω-methoxy-polyethylene glycol succinate (CHO-PEG) have been synthesized via esterification and employed at various ratios with di-stearoylphosphatidylcholine (DSPC) in the preparation of anionic long-circulating nanoliposmes for cisplatin (CDDP) delivery… (More)
DOI: 10.1016/j.biomaterials.2011.10.081

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