Cholesterol as modulator of receptor function.

  title={Cholesterol as modulator of receptor function.},
  author={Gerald Gimpl and Koert Burger and Falk Fahrenholz},
  volume={36 36},
The modulatory effect of cholesterol on the function of two structurally related peptide receptors, the oxytocin receptor and the brain cholecystokinin receptor in plasma membranes as well as in intact cells, was analyzed. Different approaches for cholesterol modification were applied: (i) depletion and reloading of cholesterol mediated by methyl-beta-cyclodextrin and cholesterol-methyl-beta-cyclodextrin, respectively, in a reversible manner; (ii) mild treatment of the plasma membranes with… CONTINUE READING
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