Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.

@article{Wood2014CholesterolAA,
  title={Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.},
  author={Wellington Gibson Wood and Ling Li and Walter E. M{\"u}ller and Gunter P Eckert},
  journal={Journal of neurochemistry},
  year={2014},
  volume={129 4},
  pages={559-72}
}
High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a decreased prevalence of AD in patients taking the cholesterol lowering drugs, statins. The strongest evidence causally linking cholesterol to AD is provided by experimental studies showing that adding/reducing cholesterol alters amyloid precursor protein (APP) and amyloid beta-protein (Ab) levels. However, there are… CONTINUE READING
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