Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes.

@article{Brown2000CholesterolAO,
  title={Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes.},
  author={Andrew J Brown and E L Mander and Ingrid C. Gelissen and Leonard Kritharides and Roger T. Dean and Wendy Jessup},
  journal={Journal of lipid research},
  year={2000},
  volume={41 2},
  pages={226-37}
}
Cholesterol- and cholesteryl ester-rich macrophage foam cells, characteristic of atherosclerotic lesions, are often generated in vitro using oxidized low density lipoprotein (OxLDL). However, relatively little is known of the nature and extent of sterol deposition in these cells or of its relationship to the foam cells formed in atherosclerotic lesions. The purpose of this study was to examine the content and cellular processing of sterols in OxLDL-loaded macrophages, and to compare this with… CONTINUE READING
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