Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

@article{Peet1998CholesterolAB,
  title={Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXR$\alpha$},
  author={D. Peet and S. Turley and Wenzhen Ma and B. A. Janowski and J. Lobaccaro and R. Hammer and D. Mangelsdorf},
  journal={Cell},
  year={1998},
  volume={93},
  pages={693-704}
}
We demonstrate that mice lacking the oxysterol receptor, LXR alpha, lose their ability to respond normally to dietary cholesterol and are unable to tolerate any amount of cholesterol in excess of that which they synthesize de novo. When fed diets containing cholesterol, LXR alpha (-/-) mice fail to induce transcription of the gene encoding cholesterol 7alpha-hydroxylase (Cyp7a), the rate-limiting enzyme in bile acid synthesis. This defect is associated with a rapid accumulation of large amounts… Expand
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice.
LXRs regulate the balance between fat storage and oxidation.
REGULATORY NETWORKS OF PXR, CAR AND LXR IN CHOLESTEROL AND BILE ACID METABOLISM
LXR is crucial in lipid metabolism.
Transcriptional and posttranscriptional control of cholesterol homeostasis by liver X receptors.
  • P. Tontonoz
  • Chemistry, Medicine
  • Cold Spring Harbor symposia on quantitative biology
  • 2011
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4
5
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References

SHOWING 1-10 OF 108 REFERENCES
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway*
Disruption of Cholesterol 7α-Hydroxylase Gene in Mice
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
Hepatic mRNA levels for the LDL receptor and HMG-CoA reductase show coordinate regulation in vivo.
  • M. Rudling
  • Biology, Medicine
  • Journal of lipid research
  • 1992
Identification and Characterization of a Mouse Oxysterol 7α-Hydroxylase cDNA*
Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols.
Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.
...
1
2
3
4
5
...