Cholesterol accumulation is increased in macrophages of phospholipid transfer protein-deficient mice: normalization by dietary alpha-tocopherol supplementation.

@article{Ogier2007CholesterolAI,
  title={Cholesterol accumulation is increased in macrophages of phospholipid transfer protein-deficient mice: normalization by dietary alpha-tocopherol supplementation.},
  author={Nicolas Ogier and Alexis Klein and Val{\'e}rie Deckert and Anne Athias and Ginette Bess{\`e}de and Naig Le Guern and Laurent Lagrost and Catherine Desrumaux},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 11},
  pages={2407-12}
}
OBJECTIVE Phospholipid transfer protein (PLTP) is a multifunctional, extracellular lipid transport protein that plays a major role in lipoprotein metabolism and atherosclerosis. Recent in vivo studies suggested that unlike systemic PLTP, macrophage-derived PLTP would be antiatherogenic. The present study aimed at characterizing the atheroprotective properties of macrophage-derived PLTP. METHODS AND RESULTS Peritoneal macrophages were isolated from PLTP-deficient and wild-type mice and their… CONTINUE READING