Cholesterol accumulation by macrophages impairs phagosome maturation.

  title={Cholesterol accumulation by macrophages impairs phagosome maturation.},
  author={Kassidy K. Huynh and Elena Gershenzon and Sergio Grinstein},
  journal={The Journal of biological chemistry},
  volume={283 51},
Macrophages are key to the pathogenesis of atherosclerosis. They take up and store excessive amounts of cholesterol associated with modified low density lipoprotein, eventually becoming foam cells that display altered immune responsiveness. We studied the effects of cholesterol accumulation on phagosome formation and maturation, using lipid transport antagonists and cholesterol transport-deficient mutants. In macrophages treated with U18666A, a transport antagonist that prevents cholesterol… CONTINUE READING
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Cholesterol Accumulation Impairs Phagosome Maturation

  • P. J. Mansfield, V. Hinkovska-Galcheva, M. S. Borofsky, J. A. Shayman, L. A. Boxer
  • Biochem. Biophys. Res. Commun
  • 2005

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