Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.

@article{Mori2001CholesterolAI,
  title={Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.},
  author={Takashi Mori and Diana Paris and Terrence C. Town and Amyn M Rojiani and D. L. Sparks and Anthony Delledonne and Fiona Crawford and Laila Abdullah and John A. Humphrey and Dennis W. Dickson and Michael J. Mullan},
  journal={Journal of neuropathology and experimental neurology},
  year={2001},
  volume={60 8},
  pages={778-85}
}
Mounting evidence suggests that cholesterol may contribute to the pathogenesis of Alzheimer disease (AD). We examined whether cholesterol might be present in senile plaques, a hallmark neuropathological feature of AD. We employed 2 different fluorometric-staining techniques (filipin staining and an enzymatic technique) for the determination of cholesterol in brains of postmortem confirmed AD patients and in nondemented, age-matched histopathologically normal controls. AD patient brains showed… CONTINUE READING

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