Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties.

@article{Doktorova2017CholesterolPP,
  title={Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties.},
  author={Milka Doktorova and Frederick A. Heberle and Richard L. Kingston and George Khelashvili and Michel A. Cuendet and Yi Wen and John Katsaras and Gerald W. Feigenson and Volker M. Vogt and Robert A. Dick},
  journal={Biophysical journal},
  year={2017},
  volume={113 9},
  pages={2004-2015}
}
Binding of the retroviral structural protein Gag to the cellular plasma membrane is mediated by the protein's matrix (MA) domain. Prominent among MA-PM interactions is electrostatic attraction between the positively charged MA domain and the negatively charged plasma membrane inner leaflet. Previously, we reported that membrane association of HIV-1 Gag, as well as purified Rous sarcoma virus (RSV) MA and Gag, depends strongly on the presence of acidic lipids and is enhanced by cholesterol (Chol… CONTINUE READING