Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins

@inproceedings{Sheng2012CholesterolMC,
  title={Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins},
  author={Ren — Sheng and Yong Chen and Heon Yung Gee and Ewa Stec and Heather R. Melowic and Nichole R. Blatner and Moe Phyu Tun and Yonjung Kim and Morten K{\"a}llberg and Takahiro K Fujiwara and Ji Hye Hong and Kwang Pyo Kim and Hui Lu and Akihiro Kusumi and Min Goo Lee and Wonhwa Cho},
  booktitle={Nature communications},
  year={2012}
}
Cholesterol is known to modulate the physical properties of cell membranes, but its direct involvement in cellular signaling has not been thoroughly investigated. Here we show that cholesterol specifically binds many PDZ domains found in scaffold proteins, including the N-terminal PDZ domain of NHERF1/EBP50. This modular domain has a cholesterol-binding site topologically distinct from its canonical protein-binding site and serves as a dual-specificity domain that bridges the membrane and juxta… CONTINUE READING
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