Cholesterol-Lowering Activity of Naringenin via Inhibition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Acyl Coenzyme A:Cholesterol Acyltransferase in Rats
@article{Lee1999CholesterolLoweringAO, title={Cholesterol-Lowering Activity of Naringenin via Inhibition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Acyl Coenzyme A:Cholesterol Acyltransferase in Rats}, author={S.-H. Lee and Y.B. Park and Ki Hwan Bae and Song Hae Bok and Y.K. Kwon and E.S. Lee and M.-S. Choi}, journal={Annals of Nutrition and Metabolism}, year={1999}, volume={43}, pages={173 - 180} }
The effects of dietary supplementation of a citrus bioflavonoid, naringenin, on the cholesterol metabolism were studied. For 42 days male rats were fed a 1% (wt/wt) high-cholesterol diet with or without a naringenin supplementation (0.1%, wt/wt) to study its effect on plasma lipid levels, hepatic lipid contents, activities of hepatic acyl coenzyme A:cholesterol O-acyltransferase (ACAT) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and the excretion of fecal neutral sterols…
123 Citations
Naringenin 7-O-cetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats.
- Chemistry, MedicineBioorganic & medicinal chemistry
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Hypocholesterolemic and antioxidative effects of naringenin and its two metabolites in high-cholesterol fed rats.
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Effect of Naringin Supplementation on Cholesterol Metabolism and Antioxidant Status in Rats Fed High Cholesterol with Different Levels of Vitamin E
- Biology, MedicineAnnals of Nutrition and Metabolism
- 2001
Naringin supplementation significantly lowered the concentrations of plasma cholesterol and triglyceride compared to the naringin-free group in low vitamin E-fed rats, indicating that naring in lowers the plasma lipid concentrations when the dietary vitamin E level is low.
Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits.
- Chemistry, MedicineBiochemical and biophysical research communications
- 2001
The results suggest that the anti-atherogenic effect of the citrus flavonoids, naringin and naringenin, is involved with a decreased hepatic ACAT activity and with the downregulation of VCAM-1 and MCP-1 gene expression.
Dietary naringenin increases hepatic peroxisome proliferators–activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats
- Biology, MedicineEuropean journal of nutrition
- 2011
The results indicate that the activation of PPARα transcription factor and upregulation of its fatty acid oxidation target genes by dietary naringenin may contribute to the hypolipidemic and anti-adiposity effects in vivo.
Supplementation of naringenin and its synthetic derivative alters antioxidant enzyme activities of erythrocyte and liver in high cholesterol-fed rats.
- BiologyBioorganic & medicinal chemistry
- 2002
Activity and mRNA Levels of Enzymes Involved in Hepatic Fatty Acid Synthesis in Rats Fed Naringenin.
- Biology, ChemistryJournal of agricultural and food chemistry
- 2015
Naringenin levels in serum and liver dose-dependently increased, and hepatic concentrations reached levels that can affect various signaling pathways, and naringen in-between levels at a dietary level of 2.5 g/kg significantly decreased the activities and the mRNA levels of various lipogenic enzymes and sterol regulatory element binding protein-1c mRNA level.
In vivo metabolic effects of naringenin in the ethanol consuming rat and the effect of naringenin on adipocytes in vitro.
- Biology, MedicineJournal of animal physiology and animal nutrition
- 2007
Results obtained in these studies demonstrate that naringenin exerts a very weak influence on carbohydrate and lipid metabolism of normal and ethanol-consuming rats and on metabolism of isolated rat adipocytes.
EFFECT OF NARINGENIN (CITRUS FLAVANONE) ON LIPID PROFILE IN ETHANOL‐INDUCED TOXICITY IN RATS
- Medicine
- 2012
The present study is aimed to identify the efficacy of naringenin by uncovering its underlying mechanism of action against alcohol-induced liver disease for effective therapy, and if the biochemical and histological findings are positive, it could be subjected to human trials in the future.
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