Cholesterol Is Required for Surface Transport of Influenza Virus Hemagglutinin

@article{Keller1998CholesterolIR,
  title={Cholesterol Is Required for Surface Transport of Influenza Virus Hemagglutinin },
  author={Patrick Keller and Kai Simons},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={140},
  pages={1357 - 1367}
}
Transport from the TGN to the basolateral surface involves a rab/N-ethylmaleimide-sensitive fusion protein (NSF)/soluble NSF attachment protein (SNAP)/SNAP receptor (SNARE) mechanism. Apical transport instead is thought to be mediated by detergent-insoluble sphingolipid-cholesterol rafts. By reducing the cholesterol level of living cells by 60-70% with lovastatin and methyl-beta-cyclodextrin, we show that the TGN-to-surface transport of the apical marker protein influenza virus hemagglutinin… CONTINUE READING
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